CD4+T Cell Subsets and Pathways to HIV Latency
نویسندگان
چکیده
منابع مشابه
CD4T lymphocyte subsets and disease manifestation in children with and without HIV born to HIV-1 infected mothers.
OBJECTIVE To understand the natural history of HIV-1 infection in children in terms of evolution of childhood clinical manifestations versus the immune status, we prospectively studied children with and without maternally transmitted HIV-1 infection born to mothers infected with HIV-1 for two years between March 1998 and March 2000. DESIGN A prospective cohort study. SETTING An institutiona...
متن کاملBioinformatics and HIV Latency
Despite effective treatment, HIV is not completely eliminated from the infected organism because of the existence of viral reservoirs. A major reservoir consists of infected resting CD4+ T cells, mostly of memory type, that persist over time due to the stable proviral insertion and a long cellular lifespan. Resting cells do not produce viral particles and are protected from viral-induced cytoto...
متن کاملHIV latency.
HIV-1 can establish a state of latent infection at the level of individual T cells. Latently infected cells are rare in vivo and appear to arise when activated CD4(+) T cells, the major targets cells for HIV-1, become infected and survive long enough to revert back to a resting memory state, which is nonpermissive for viral gene expression. Because latent virus resides in memory T cells, it per...
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DC are key regulators of immunity in view of the fact that they are involved in immune re‐ sponses against infectious diseases, allergy and cancer [1, 2]. Ralph Steinman was awarded the Nobel Prize for Medicine 2011 for DC discovery in 1973 [3]. Steinman and Cohn [3] de‐ scribed a novel cell type in mouse spleen, which they named ́dendritic cell ́ due to their tree-like shape. The major function ...
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Methods We identified several levels of transcriptional and posttranscriptional control of viral genes expression. By looking at the organization of chromatin at the site of integration by chromatin conformation capture and in situ hybridization, we found that chromatin imposes silencing in a highly specific spatial and temporal pattern. We also identified several cellular factors that interact...
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ژورنال
عنوان ژورنال: AIDS Research and Human Retroviruses
سال: 2018
ISSN: 0889-2229,1931-8405
DOI: 10.1089/aid.2018.0105